• Non-healing and infected wounds - ulcers
• Diabetic ulcers (prevention of amputation)
• Venous and arterial insufficiency ulcers
• Pressure sores from wheel chair or bed rest confinement
• Bone infections such as osteomyelitis
• Radiation tissue injury in patients treated for cancer
• Necrosis of bone or soft tissue in patients being treated for cancer
• Bacterial infections (subcutaneous, muscle, fascia)
• Burns (improved tissue salvage, faster recovery and minimal scarring)
• Carbon monoxide poisoning, cyanide poisoning, smoke inhalation
• Extreme loss of blood or anemia - when blood transfusion is not an option

In acute cases, such as air/gas embolism and decompression sickness, hyperbaric oxygen therapy is the primary health care method.