Project HORTIS – Hyperbaric Oxygen and Radiation Therapy Injury Study

HORTIS was developed as a multi-centre study with international participation, involving a randomized, double blind, placebo-controlled clinical trial, with patient cross-over option.

The principle objective of this research was to more precisely determine the degree of benefit that hyperbaric oxygen therapy affords in the treatment of late radiation tissue injury.

The study had eight components. Seven involve evaluation of established radionecrosis at varying anatomic sites (mandible, larynx, skin, bladder, rectum, colon, and gynaecological). The eighth will investigate the potential of hyperbaric oxygen therapy to prevent late radiation tissue injury.

Recently results for HORTIS IV (radiation proctitis) have been published in the International Journal of Radiation Oncology Biology Physics Vol 72; No 1, 2008.  Click here to view the results.The results indicate very favourable results two years after treatment with a course of HBO.

For further information on Project HORTIS, please contact The Baromedical Research Foundation.